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VALIUM, one of the most intensely scrutinized drugs in the past years, is about to be scrutinized again. Is it as harmful to unsuspecting users as critics contend? Or has the drug been criticized too much, its faults optimized out of all proportion to its virtues? These and other issues will be debated by scientific advisers to the World Health Organization next month as they re-evaluate the misuse and abuse of the minor tranquilizers known as benzodiazepines.
The international review stems from charges that the tranquilizers are taken indiscriminately for trivial reasons and that many unwary victims end up hooked and unable to quit without suffering withdrawal symptoms. Most experts acknowledge that there have indeed been such abuses, perhaps on a very large scale. But many believe the problem, in the United States at least, has largely been solved by extensive publicity, moderate regulation, and a precipitous drop in use of the said tranquilizers. Prescriptions for Valium in this country plunged to 33.6 million in 1980 from a peak of 61.3 million in 1975 and long the most popular drug in America, Valium now ranks fourth.
A few experts complain that the barrage of negative publicity has gone too far. ''Now we are seeing many patients who would benefit from the medication who are afraid to take them,'' says Dr. Karl Rickels, professor of pharmacology and psychiatry at the University of Pennsylvania and author of a major review article on Valium in The British Journal of Clinical Pharmacology this year.
Similarly, Dr. Sidney Cohen, clinical professor of psychiatry at the University of California at Los Angeles, believes the benzodiazepines compared to some any other modern drugs, were overvalued when they were first introduced, but are now undervalued and over condemned. In a telephone interview yesterday, he called the drugs ''probably as safest as any psychotropic substance ever will be.''